eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally

eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally.

At birth, the transition to gas breathing requires the function of endothelial vasoactive agents. We investigated the function of endothelial nitric oxide synthase (eNOS) in pulmonary artery (PA) vessels and endothelial cells isolated from fetal and young (4-wk) sheep. We found greater relaxations to the NOS activator A-23187 in 4-wk-old compared with fetal vessels and that the NOS inhibitor ni...

Uncoupling of eNOS by ONOO-

eNOS uncoupling in pulmonary hypertension.

Pulmonary arterial hypertension (PAH) is characterized by high blood pressure and vascular remodelling in pulmonary arteries and subsequently right ventricular hypertrophy. Although several studies in animal models of pulmonary hypertension (PH) and pathological examinations of lung tissue obtained from PAH patients show occlusion of pulmonary arteries, the exact molecular mechanisms for vascul...

Endothelial GTPCH in eNOS uncoupling and atherosclerosis.

Nitric oxide (NO) produced from endothelial NO synthase (eNOS) has antiatherosclerotic properties, including inhibition of cell growth, leukocyte adhesion, and platelet adherence and aggregation.1 NO bioavailability is decreased in various cardiovascular diseases such as hypercholesterolemia and atherosclerosis attributable to reduced NO synthesis and increased NO consumption by reactive oxygen...

Anti-atherosclerotic effects of small molecular weight compounds enhancing eNOS expression and preventing eNOS uncoupling